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Every individual’s immune system is distinct and changes over time, affecting their health and disease response. Recently, researchers mapped human immune cells to explore what defines a healthy immune system across different ages. 
“None of the [current immune-based] atlases were actually robust enough for our purposes,” said Claire Gustafson, an immunologist at the Allen Institute for Immunology, who led the Human Immune Health Atlas project to gain insight into the immune system’s complexity and diversity.
First, the team established their atlas criteria: a wide age range, more cells per person compared to other atlases, and a large pool of donors to capture population and individual heterogeneity. They used flow cytometry and single-cell RNA sequencing on more than 1.8 million cells from healthy male and female donors from the ages of 11–65 years old.
“While a lot of other available atlases have in the thousands of cells per person, when you look at rarer subsets, you’ll be missing those,” said Gustafson. “We actually did much deeper sequencing on a per sample level, where we got greater than 10,000 cells per person to build this map.”
From this vast cellular landscape, the researchers annotated 71 distinct immune cell subsets and generated a vibrant atlas depicting swaths of color. In the above image, each colored dot represents an immune cell, and dots of the same color belong to the same cell type, based on their gene expression.
The team observed changes in immune cell composition across the age groups. Building upon this atlas, described in a preprint, the researchers analyzed more than 16 million cells across the same immune cell subsets, discovering that T cells were primarily affected over time than other immune cells.¹
“Deeply characterizing the immune system is going to be critical in designing better vaccines, age-specific therapeutics, and really gain insight into how changes might start and cause dysregulation,” said Gustafson.
This exclusive article was first published in TS Digest
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This photo provided by Hanwha Aerospace shows Michael Coulter, former president of global defense firm Leonardo DRS International, who has been appointed as the South Korean defense equipment maker's new global defense CEO. [YONHAP]
Hanwha Aerospace taps ex-president of U.S. defense firm for global business chief
Maeil Dairies apologizes for cleaning solution accident in milk production
Hyundai AutoEver establishes joint venture on Southeast Asia navigation maps
Science ministry to invest $1.9 billion for climate change
Energy company Aramco leads the way in tackling plastic waste in Seoul
Hanwha shakes up its corporate structure, grouping related businesses together
Korea’s arms contractors strike major deals overseas [REWIND 2023]
Hanwha to invest 37.6 trillion won into energy, carbon neutrality, defense
Hanwha Aerospace completes construction of first overseas production facility
Hanwha Aerospace posts 965.5% net growth
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SHANGHAI, Dec. 15, 2024 /PRNewswire/ — The Cambridge Generative AI in Education Conference 2024 recently concluded in Cambridge, UK. The event was co-organized by the Faculty of Education at the University of Cambridge, the College of Education for the Future at Beijing Normal University, the Digital Education Futures Initiative (DEFI) at the University of Cambridge’s Hughes Hall, and the Glenlead Centre in London. Dr. Joleen Liang, co-founder of Squirrel Ai Learning, participated as a keynote speaker. 

The conference, themed “Human-Machine Collaboration and the Expansion of the Dialogic Space,” explored the role of artificial intelligence (AI) in driving innovation in education, improving teaching outcomes, enhancing student engagement, and redefining the role of educators. The event brought together thought leaders, researchers, and policymakers from around the world to discuss the opportunities and challenges of AI in education. 
AI in Education: A Mix of Joys and Concerns
During a panel discussion titled “AI in Education: Friend or Foe,” Dr. Ann Kristin Glenster of the University of Cambridge, Prof. Jenny Gibson of Neurodiversity and Developmental Psychology at the University of Cambridge, Prof. Yuan Li of Beijing Normal University, Co-chair Kellie Mote of the JISC Accessible Digital Futures Project, and Dr. Joleen Liang of Squirrel Ai shared their perspectives on the future of AI in education. 
Dr. Liang said that AI education should prioritize educational needs rather than just the technology itself. She noted that companies and researchers often become overly focused on AI advancements while neglecting the fundamental needs of education.
In K-12 education, it’s crucial for students to engage in problem-solving through active thinking and learning processes, rather than simply looking for direct answers. Squirrel Ai’s adaptive system was designed with this philosophy in mind, leveraging over 10 billion learning behavior records to analyze students’ strengths and weaknesses. By offering personalized learning recommendations instead of instant answers, the approach fosters cognitive development and discourages AI dependency. 
Dr. Liang explained that AI would complement teachers by assuming roles in knowledge transfer and skills training, while they would increasingly act as supervisors, data analysts, and psychologists. In Squirrel Ai’s system, educators focus on facilitating student learning rather than direct content delivery.  
Prof. Yuan Li emphasized the importance of using AI technology to drive educational innovation and prepare future teachers. Given the novelty of generative AI and related technologies, extensive research is needed to understand their implications, especially in teacher education. “Improving teachers’ AI skills is crucial, as they need to understand and apply these technologies,” said Prof. Yuan. “In China, there is significant policy support, and many companies have integrated large models into education systems for classroom use. To this end, our main focus is on how these technologies affect teachers’ practical teaching methods.”
Prof. Jenny Gibson saw great potential in integrating generative AI into relevant platforms and using it as an effective teaching method. However, she doesn’t expect teachers to be replaced any time soon, as “old-fashioned” learning methods and in-person classroom experiences remain crucial. 
Kellie Mote, co-chair of the JISC Accessible Digital Futures Project, commented that while AI holds great promise, it’s not a panacea. She advocated for responsible and trustworthy integration of AI technologies into educational settings.
Squirrel Ai Committed to Advancing AI Education
The conference highlighted the integration of generative AI in education and its transformative impact on academic practices, instructional design, and assessment. Keynote speeches included insights from several thought leaders.
Prof. Wayne Holmes from University College London presented “AI and Education: A Critical Studies Perspective,” examining AI’s role in education, debunking misconceptions, and addressing ethical challenges. He discussed balancing AI technology with education equity and human rights.
Prof. Rupert Wegerif from the University of Cambridge’s Faculty of Education spoke on “Generative AI and Expanding Dialogic Space,” exploring how generative AI fosters better thinking and communication among students. He advocated for leveraging AI technology to support education, aiming to enhance dialogic competence and benefit students in interdisciplinary and global dialogues.
Dr. Joleen Liang delivered a speech titled “Revolutionizing Personalized Learning through AI,” sharing Squirrel Ai’s research findings and insights on AI and personalized learning with international educators.
Since its inception, Squirrel Ai has invested over 2 billion yuan in technology research and development to advance AI in education. Leveraging over 10 billion student learning behaviors accumulated over the years, the company has developed the multimodal Large Adaptive Model (LAM) – the world’s first large model integrating adaptive technology with multimodal large models in the education sector. 
By leveraging its proprietary AI adaptive learning and teaching platform, Squirrel Ai is expanding into the smart hardware domain. Its comprehensive suite includes AI-enhanced core skills development, intelligent diagnostic assessments, in-depth knowledge evaluations, sequential learning, MCM learning strategies, skill mastery training, mistake analysis, spaced repetition, error tracking journals, performance feedback reports, and Level 5 AI-driven interactive teaching capabilities. The technology has earned widespread acclaim from parents, students, and educators alike.
Furthermore, Squirrel Ai has provided robust commercial support for the rapid adoption of its multimodal adaptive learning system through the efficient expansion of its offline stores. With over 2,000 physical smart learning tablet stores nationwide, Squirrel Ai is now the largest AI learning device brand by retail footprint in China. Looking ahead, Squirrel Ai remains committed to providing every child with the best AI teacher.
Dr. Joleen Liang also said that Squirrel Ai has formed the AI Education Large Model Standards Committee to establish standards for AI in education. While trust in technology is essential, setting parameters and norms is critical. This requires a comprehensive consideration of the technical and knowledge aspects of education to ensure the effectiveness and safety of AI systems.
Looking ahead, Squirrel Ai remains committed to the research and development of its multimodal LAMs, maintaining its leadership in technological innovation while consistently advancing personalized learning. By introducing new and innovative approaches, Squirrel Ai is driving changes in educational models, methodologies, and resources, creating new opportunities for the future of education.
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12 minutes ago copy link Manoj Bajpayee is in the news these days about his film Dispatch. Meanwhile, the actor has shared some interesting stories about his personal life. He told- I had an interfaith marriage with Shabana Raza. There was no family pressure on me regarding marriage. ‘I and Shabana respect each other’s religion’ […]
By Qrius

12 minutes ago
Manoj Bajpayee is in the news these days about his film Dispatch. Meanwhile, the actor has shared some interesting stories about his personal life. He told- I had an interfaith marriage with Shabana Raza. There was no family pressure on me regarding marriage.

‘I and Shabana respect each other’s religion’
While talking about his marriage, Manoj Bajpayee said- My father was a very broad minded person. That’s why he was never against my relationship. I also tell my daughter that she should take her own decision regarding her religion. Both Shabana and I respect each other’s religion a lot. Since we both have different religions, there is never any issue in our house. Everyone has their own space regarding religion.
There were more Muslim people in father’s funeral – Manoj
During a conversation with Barkha Dutt, Manoj Bajpayee was asked that how was the experience of marrying a Muslim girl? Responding to which the actor said that I did not face any problem. My father was a gentleman, he was very friendly and many of his friends were Muslims. More Muslims than Hindus came to his funeral. That’s how I was brought up.
My daughter asked what is my religion- Manoj
The actor further said- Now there is a discussion at home about my daughter’s religion and which religion she will follow. My daughter once asked her mother – What is my religion? So I and his mother said that it is your decision as to which religion you want to follow.
I pray daily- Manoj
During this conversation, Manoj told that he worships in the temple every day. Whereas, his wife follows her religion. They do not discuss anything about religion at home.
Manoj Bajpayee plays investigative journalist in the film Dispatch
Recently released movie on Zee5
Talking about Manoj Bajpayee’s upcoming project, he is in the news these days for the film Dispatch. This film has been released on OTT platform Zee5 on 13 December. Apart from Manoj, Shahana Goswami, Rituparna Sen are in lead roles in this film. This film is being discussed a lot on social media.

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Jackpot: $3M Pennsylvania Lottery ticket sold over the weekend  WTAJ – www.wtaj.com
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The Eagles remain at Lincoln Financial Field for the second week in a row for a battle of Pennsylvania with the Pittsburgh Steelers.
The 11-2 Eagles are coming off of a 22-16 win over the Panthers, while the 10-3 Steelers took down the Browns, 27-14.
Find out how to watch, stream, or listen to the action here:
Television and Streaming
Sunday’s game will kick off at 4:25 PM ET on FOX with Kevin Burkhardt and Tom Brady on the call. Erin Andrews and Tom Rinaldi will be on the sidelines reporting. If you live outside of the local markets, click here to see if the game is being televised in your area.
Fans outside of the local markets can also stream the game on the league’s exclusive video streaming subscription service – NFL+. In addition to live out-of-market preseason games, NFL+ also features live local and prime-time regular-season and postseason games (phone and tablet only) as well as live local and national audio for every game, NFL Network shows on-demand, NFL Films archives, and more.
Beyond the United States, fans in Australia and New Zealand can watch the game live on ESPN PacRim.
For a comprehensive list of the ways to watch the Eagles in action this season, check out the NFL’s Ways to Watch page.
Listen
Hear the iconic voices of Merrill Reese and Mike Quick calling the game on SportsRadio 94WIP. The desktop version of PhiladelphiaEagles.com/LiveRadio will provide a live feed of the SportsRadio 94WIP broadcast that is available in the United States. Fans can also listen on the Eagles app as well in the Philadelphia market.
Rickie Ricardo, Oscar Budejen, and Dave Gerhardt will provide the Eagles’ Spanish-language radio broadcast courtesy of Tico Sports | Eagles en Español on La Mega 105.7 FM in Philadelphia, 93.9 FM in Atlantic City, and 103.3 FM in Vineland/Millville. The desktop version of PhiladelphiaEagles.com/LiveRadio will also provide a feed of the Spanish version. Fans in the Philadelphia market can also listen to the Spanish version on the Eagles app.
Fans in the Pittsburgh market can listen locally on WDVE 102.5 FM and WBGG 970 AM. – Compiled by Liam Wichser
Walter Payton Man of the Year | 2024 Nominee Brandon Graham
The Philadelphia Eagles have announced Brandon Graham as its nominee for the Walter Payton NFL Man of the Year Award presented by Nationwide. Considered one of the league’s most prestigious honors, the award recognizes an NFL player for outstanding community service activities off the field, as well as excellence on the field.
The Eagles host the AFC North-leading Steelers with an eye on a franchise-record 10th straight win.
Reed Blankenship and Sydney Brown are back in the lineup after missing last week’s game.
Since Week 6, these are two of the best teams in the NFL in terms of record, points scored, point differential, turnover margin, and time of possession. This is going to be a fantastic intrastate matchup with a playoff atmosphere.
With the Commanders win, the Eagles will have to wait one more week to try and clinch the NFC East.
The former defensive tackle was a member of the 1960 NFL Championship Team and the Eagles’ Defensive MVP in 1962.
The rookie was added to the injury report with an illness on Friday.
Britain Covey will miss a second straight game. Reed Blankenship and Sydney Brown are good to go after missing the Panthers game.
The Eagles rank fourth in the NFL in votes by team. See where players rank for their position in the voting thus far.
The talented men and women who represent the Eagles organization as global brand ambassadors are led internally by a phenomenal group of eight captains.
Pittsburgh leads the league in takeaways and is fourth in run defense. The battle in the trenches will be marvelous come Sunday afternoon.
Hinton is the Executive Director of PA Youth Vote and President of the Norristown National Association for the Advancement of Colored People.
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‘Race-blind charges’: Another Northern California prosecutor to redact racial identifiers when making charging decisions  KTXL FOX 40 Sacramento
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