Dec 16, 2024
Share this article:
The following is a summary of “Estimating the effect of COVID-19 vaccination and prior infection on Ct values as a proxy of SARS-CoV-2 viral load,” published in the December 2024 issue of Infectious Disease by Andeweg et al.
Researchers conducted a retrospective study to assess the effect of COVID-19 vaccination and prior infection status on RT-qPCR cycle threshold (Ct) values while considering the virus variant as a factor.
They used Dutch SARS-CoV-2 community testing data (n = 4,09,925 samples) from March 8, 2021, to December 31, 2022. Separate univariable linear regressions were performed for each explanatory variable, including age, sex, testing date, variant of infection, time since symptom onset, and testing laboratory. Causal inference analysis was then conducted to evaluate the impact of prior infection and vaccination status on Ct values, applying inverse propensity score weighting to adjust for confounders.
The results showed a negative correlation between age and Ct values. Modest differences in Ct values were observed across variants of infection, with Omicron variants showing lower Ct values (higher viral load) compared to earlier variants. The Ct values increased (indicating lower viral load) with prior infection. However, the effect of vaccination on Ct values was less significant.
Investigators concluded the prior infection was associated with higher Ct values, suggesting a potential decrease in viral load and potentially lower transmissibility.
Source: ijidonline.com/article/S1201-9712(24)00437-5/fulltext
View all posts
The latest articles and insights from your colleagues in your specialty(ies) of choice.
SUBSCRIBE NOW
View all newsletters
Dec 16, 2024
Dec 16, 2024
Dec 16, 2024
Dec 16, 2024
Dec 16, 2024
Dec 16, 2024
The latest articles and insights from your colleagues in your specialty(ies) of choice.
SUBSCRIBE NOW
View all newsletters
Dec 16, 2024
Dec 16, 2024
Dec 16, 2024
Dec 16, 2024
Dec 16, 2024
Dec 16, 2024
Insights from the leaders in medical research, trending topics in clinical medicine, and perspectives from your colleagues.
Subscribe to our free Newsletters to receive weekly emails, and even get a laugh or two from our medical cartoons.
SUBSCRIBE NOW
About Physician’s Weekly
Careers
Memberships & Verifications
Press
Advertise With Us
Our Partners
Blog
Terms & Conditions
Privacy Policy
Editorial Policy
Contact Us
Figure1.com
OncWeekly.com
The content of this site is intended for healthcare professionals.
Any views and opinions expressed are those of the author(s) and/or participants and do not necessarily reflect the views, policy, or position of Physician’s Weekly, their employees, and affiliates.
English 
Français