Author: Eric Mawuli DJIRACKOR

Posted on by — Leave a comment

Herb-Drug Interactions – National Center for Complementary and Integrative Health

An official website of the United States government
Here’s how you know
NCCIH Clinical Digest
for health professionals
The possibilities of drug interactions, direct toxicities, and contamination with active pharmaceutical agents are among the safety concerns about dietary and herbal supplements. Although there is a widespread public perception that herbs and botanical products in dietary supplements are safe, research has demonstrated that these products carry the same dangers as other pharmacologically active compounds. Interactions may occur between prescription drugs, over-the-counter drugs, dietary supplements, and even small molecules in food—making it a daunting challenge to identify all interactions that are of clinical concern.
Concerns about herb-drug interactions are often not based on rigorous research. Most herb-drug interactions identified in current sources are hypothetical, inferred from animal studies or cellular assays, or based on other indirect means; however, attention to this issue is needed for drugs with a narrow therapeutic index, such as cancer chemotherapeutic agents, warfarin, and digoxin.
To date, well-designed clinical studies evaluating herbal supplement–drug interactions are limited and sometimes inconclusive. This issue of the Digest provides information about several herbs and their potential interactions with other agents.
What the Science Says: 
Herb-Drug Interactions
There are uncertainties about whether ginseng might interact with certain medications, such as calcium channel blockers and other high blood pressure medications, as well as statin medications and some antidepressants. Studies on the effect of Asian ginseng on the anticoagulant warfarin have had mixed results.
Read more about the efficacy and safety profile of Asian ginseng
Cat’s claw may interact with anticoagulant/antiplatelet drugs, hypertensive drugs, calcium channel blockers, cytochrome P450 3A4 (CYP3A4) substrates, and immunosuppressants.
Read more about the efficacy and safety profile of cat's claw
Preliminary studies suggest that taking chamomile along with birth control pills might decrease the effects of oral contraceptives. 
Interactions between chamomile and some drugs metabolized by the liver and warfarin have been reported, and there are theoretical reasons to suspect that chamomile might interact with other drugs as well, such as sedatives.
Read more about the efficacy and safety profile of chamomile
There is conflicting evidence about whether cranberry interacts with the anticoagulant warfarin.
Read more about the efficacy and safety profile of cranberry
Taking Ginkgo biloba with warfarin is associated with increased risk for major bleeding events compared to warfarin alone. Concomitant use of Ginkgo biloba preparations and efavirenz (a non-nucleoside reverse transcriptase inhibitor) is not recommended.
Read more about the efficacy and safety profile of ginkgo
A study funded by the National Center for Complementary and Integrative Health (NCCIH) found that levels of metformin decreased about 25 percent in healthy adults who were given goldenseal extract plus metformin. This drop was enough to potentially hinder glucose control in people with type 2 diabetes taking metformin.
Read more about the efficacy and safety profile of goldenseal
Green tea at high doses has been shown to reduce blood levels and, therefore, the effectiveness of the drug nadolol, a beta-blocker used for high blood pressure and heart problems. Green tea extract can reduce blood levels of the cholesterol-lowering drug atorvastatin. Green tea may also interact with other medicines.
Read more about the efficacy and safety profile of green tea
St. John’s wort has been found to have an overall high risk of drug interaction because it is a potent inducer of both cytochrome P-450 enzymes and intestinal P-glycoprotein.
Clinically significant interactions with St. John’s wort and the immunosuppressant drug cyclosporine, the antiretroviral agent indinavir, oral contraceptives, coumadin, digoxin, and benzodiazepines, among others, have been documented.
Read more about the efficacy and safety profile of St. John's wort
NCCIH Clinical Digest is a service of the National Center for Complementary and Integrative Health, NIH, DHHS. NCCIH Clinical Digest, a monthly e-newsletter, offers evidence-based information on complementary health approaches, including scientific literature searches, summaries of NCCIH-funded research, fact sheets for patients, and more.
The National Center for Complementary and Integrative Health is dedicated to exploring complementary health products and practices in the context of rigorous science, training complementary health researchers, and disseminating authoritative information to the public and professionals. For additional information, call NCCIH’s Clearinghouse toll-free at 1-888-644-6226, or visit the NCCIH website at nccih.nih.gov. NCCIH is 1 of 27 institutes and centers at the National Institutes of Health, the Federal focal point for medical research in the United States.
Content is in the public domain and may be reprinted, except if marked as copyrighted (©). Please credit the National Center for Complementary and Integrative Health as the source. All copyrighted material is the property of its respective owners and may not be reprinted without their permission.
Subscriptions
NCCIH Clinical Digest is a monthly e-newsletter that offers evidence-based information on complementary and integrative health practices.
Clinical Digest Archive
Follow NCCIH:
Contact Us
NCCIH Home
National Institutes of Health
U.S. Department of Health & Human Services
USA.gov
9000 Rockville Pike
Bethesda, Maryland 20892
Privacy and Policies
Accessibility
FOIA
Vulnerability Disclosure
en Español
Site Map
Archive
NIH…Turning Discovery Into Health®
Site Last Updated: December 20, 2024
Follow NCCIH:
Contact Us
Privacy and Policies
Accessibility
FOIA
Vulnerability Disclosure
en Español
Site Map
Archive
NCCIH Home
National Institutes of Health
U.S. Department of Health & Human Services
USA.gov
9000 Rockville Pike
Bethesda, Maryland 20892
NIH…Turning Discovery Into Health®
Site Last Updated:

source

Posted on by — Leave a comment

OKCPS reassures commitment to equitable education, regardless of proposed citizenship rule – KOKH FOX25

Now
34
Sat
52
Sun
58
by Hadley Waldren
TOPICS:
OKLAHOMA CITY, OKLA (KOKH) — Oklahoma City Public Schools (OKCPS) released a statement in response to the Oklahoma State Department of Education's (OSDE) proposed proof of citizenship rule.
OKCPS stated that the district will monitor developments but will continue to follow law and board policy.
Federal law guarantees a right to public education for all children regardless of immigration status.
Dr. Jamie C. Polk, OKCPS Superintendent stated the following:
For more local news delivered straight to your inbox, sign up for our daily newsletter by clicking here.

source

Posted on by — Leave a comment

In escalating legal feud, Tony Buzbee files lawsuit against Roc Nation, Jay-Z lawyers – USA TODAY

The legal feud between rapper Jay-Z and celebrity lawyer Tony Buzbee escalated Wednesday with the filing of yet another lawsuit.
The attorney’s Buzbee Law Firm filed a suit against Roc Nation, the entertainment company founded by Jay-Z, as well as lawyer Marcy Croft and law firm Quinn Emanuel, accusing all three of violating various Texas state laws by allegedly offering a former client money in exchange for suing Buzbee’s firm.
This suit, filed in Harris County, Texas, punctuates a growing dispute between Buzbee, who represents many of the accusers in the flurry of rape cases against music mogul Sean “Diddy” Combs, and Jay-Z, who is accused in one such suit of assaulting a minor alongside Combs.
Marcy Croft works with Team Roc, Roc Nation’s philanthropic arm. Quinn Emanual’s firm is representing Jay-Z in both Buzbee’s original case against Combs and the rapper in New York and the countersuit filed by Jay-Z in Los Angeles court.
“Tony Buzbee has now conjured up fantastical allegations against me and my firm — well-known corruption fighters — in a desperate attempt to distract from his mounting legal woes.  We look forward to addressing these false allegations and having them dismissed,” Marcy Croft shared in a statement with USA TODAY Wednesday.
Need a break? Play the USA TODAY Daily Crossword Puzzle.
Roc Nation echoed that sentiment, sharing in their own statement to USA TODAY: “Tony Buzbee’s baloney lawsuit against Roc Nation is nothing but another sham. It’s a pathetic attempt to distract and deflect attention. This sideshow won’t change the ultimate outcome and true justice will be served soon.”
Buzbee announced the newest suit, brought on behalf of a former client of his firm, Wednesday with a post on Instagram. The filings allege that agents for the lawyers posed as employees of the state of Texas, “flashed fake badges” and offered the client up to $10,000 to sue the Buzbee Law Firm. The funding for the alleged “conspiracy” came from Roc Nation, the suit argues.
Sean ‘Diddy’ Combs’alleged drug mule’s criminal case dropped
The lawyer, known for taking on high-profile cases, offered as evidence an alleged transcript of a call between the defendants and Buzbee’s former client in which they offered to pay him.
“This illegal conduct has happened more than two dozen times to date and has resulted in two utterly frivolous cases against the firm,” Buzbee wrote in the post and in a statement shared with USA TODAY.
Buzbee was sued in November by an unnamed “high-profile” celebrity for “shamelessly attempting to extort exorbitant sums from him.” Jay-Z has since come forward as that celebrity.
“This conduct was specifically targeted at our firm so we would not pursue cases related to the Diddy litigation. LET ME BE CLEAR: we will not be bullied or intimidated,” he wrote. “The Defendants overstepped, got sloppy, and stupidly got caught in their illegal scheme on tape.”
USA TODAY has reached out to Quinn Emanuel for comment.
After being ensnared in the continuously growing legal minefield facing Combs, Jay-Z vigorously denied the accusations against him and took aim at Buzbee specifically. “I have no idea how you have come to be such a horrible human Mr. Buzbee,” the “Empire State of Mind” rapper wrote in a statement shared at the time, “but I promise you I have seen your kind many times over.”
Jay-Z’s response to rape allegationshocked. Our reaction matters, too.
Going on the offensive, lawyers for Jay-Z sent a letter to the judge in the New York case last week accusing Buzbee and his associates of pressuring clients to include Combs in their accusations.
“We don’t pressure people nor do we need to. What we have done is reject potential cases from people we find to not be credible,” Buzbee shared in a statement with USA TODAY at the time.
Jay-Z is accused in a civil suit of taking turns with Combs in raping the aforementioned minor, who said she was 13 when the alleged assault took place, at an MTV Video Music Awards after-party in September 2000.
Combs and Jay Z’s accuser has since come forward publicly, acknowledging discrepancies in her story but that the accusation stands. The alleged victim said her father picked her up from the party where she says she was assaulted, but he denied that claim. She also claimed she talked to a celebrity at the event, but the celebrity said she was not in New York at the time the party took place.
“You should never let what somebody else did ruin or run your life. I just hope I can give others the strength to come forward like I came forward,” the woman, now 38, told NBC News.
This weekend’s “investigative report proves this ‘attorney’ Buzbee filed a false complaint against me in the pursuit of money and fame. This incident didn’t happen and yet he filed it in court and doubled down in the press. True Justice is coming,” Jay-Z shared in a statement via representatives Saturday, adding that “this was over before it began” and “this 1-800 lawyer doesn’t realize it yet.” 
When the sprawling case against Combs kicked off, Buzbee held a press conference in which he shared a 1-800 number for potential victims to contact him.
Combs is accused of sex trafficking and racketeering and faces several civil suits from individual alleged victims outlining a seeming pattern of abuse that dates back decades.
If you are a survivor of sexual assault, you can call the National Sexual Assault Hotline at 800.656.HOPE (4673) or visit hotline.rainn.org/online and receive confidential support.
Contributing: KiMi Robinson, Jay Stahl

source